Potassium Carbonate → 4-Amino-2-methylpyrimidine-5-carbonitrile

HRID 1287672Notes

Reaction equation

HRID 1287672 reaction equation
C(=O)([O-])[O-].[K+].[K+].[NH2:7][C:8]1[N:9]=[C:10]([CH3:16])[NH:11][CH2:12][C:13]=1[C:14]#[N:15]>[Fe-3](C#N)(C#N)(C#N)(C#N)(C#N)C#N.[K+].[K+].[K+].O>[NH2:7][C:8]1[C:13]([C:14]#[N:15])=[CH:12][N:11]=[C:10]([CH3:16])[N:9]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 178433162HCID 178433162, compound

Product 1

HCID 696824-Amino-2-methylpyrimidine-5-carbonitrile

Reagents, catalysts & solvents 2

HCID 178511488HCID 178511488, compoundCatalystHCID 962WaterSolvent

Conditions

Temperature
10 °C

Procedure

1.6 g. of potassium carbonate and 0.1 g. of potassium ferricyanide are added to a suspension of 1.35 g. of 4-amino-5-cyano-1,6-dihydro-2-methyl-pyrimidine in 25 ml. of water. A moderately strong stream of chlorine gas is bubbled through the mixture, which has been cooled to 10° C. with stirring. Initially, all the reactants are dissolved. Subsequently, a precipitate forms. The reaction is completed when excess chlorine is detectable. The reaction normally takes 3 hours. The 4-amino-5-cyano-2-methyl-pyrimidine obtained after re-precipitation from dilute sulfuric acid/dilute sodium hydroxide, has a melting point of 258°-259° C.

Workup

  1. customA moderately strong stream of chlorine gas is bubbled through the mixture, which
  2. dissolutionInitially, all the reactants are dissolved
  3. customThe reaction normally takes 3 hours

Sources & evidence

ORD record
ord-b49e363268374ef4819b3a7b22547ae3
Source dataset
uspto-grants-1976_10
Patent number
US03985785

Reaction notes

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