Sodium Iodide → HCID 21506239, compound

HRID 1287681Notes

Reaction equation

HRID 1287681 reaction equation
Br[CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:11]([Cl:21])[CH:10]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[I-:22].[Na+]>CC(C)=O>[I:22][CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:11]([Cl:21])[CH:10]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 21506232HCID 21506232, compound

Product 1

HCID 21506239HCID 21506239, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 37.3 g. (0.1 moles) of ethyl α-bromo-β-(3-chloro-4-cyclohexylphenyl)propionate and 150 g. of sodium iodide in 1 liter of anhydrous acetone is refluxed for 4 hours. The reaction mixture is then evaporated to dryness and extracted with ether. The ether is then washed with water, dried and evaporated to dryness to obtain ethyl α-iodo-β-(3-chloro-4-cyclohexylphenyl)propionate.

Workup

  1. additionA mixture of 37.3 g
  2. customThe reaction mixture is then evaporated to dryness
  3. extractionextracted with ether
  4. washThe ether is then washed with water
  5. customdried
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-df38fadf314c45e480189833cb8e87fd
Source dataset
uspto-grants-1976_10
Patent number
US03985788

Reaction notes

Loading…