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HRID1287724

反应详情

EQUATION

反应方程式

HRID 1287724 的结构方程式

REACTANTS

反应物

2
结构：Cc1cccc(N)c1
HCID7934

3-Methylaniline

C7H9N

结构：NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Cl
HCID89893

4-Chloro-3-nitro-5-sulphamoylbenzoic acid

C7H5ClN2O6S

PRODUCTS

生成物

1
结构：Cc1cccc(Nc2c([N+](=O)[O-])cc(C(=O)O)cc2S(N)(=O)=O)c1
HCID21505988

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A mixture of 4-chloro-3-nitro-5-sulphamyl-benzoic acid (28 g), m-toluidine (32.2 g), and water (500 ml) was refluxed for 3 hours. After cooling and acidification with 2N hydrochloric acid, the precipitated 3-nitro-5-sulphamyl-4-(m-toluidino)-benzoic acid was collected by suction, washed with water, and recrystallized from isopropanol. After drying at 115° C in vacuo, the melting point was 256°-259° C.

WORKUP

后处理

  1. temperaturewas refluxed for 3 hours
  2. temperatureAfter cooling
  3. customacidification with 2N hydrochloric acid, the precipitated 3-nitro-5-sulphamyl-4-(m-toluidino)-benzoic acid was collected by suction
  4. washwashed with water
  5. customrecrystallized from isopropanol
  6. customAfter drying at 115° C in vacuo