huagongshe.com
HRID1287742

反应详情

EQUATION

反应方程式

HRID 1287742 的结构方程式

REACTANTS

反应物

2
结构：CC(C)N
HCID6363

Isopropylamine

C3H9N

结构：NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Cl
HCID89893

4-Chloro-3-nitro-5-sulphamoylbenzoic acid

C7H5ClN2O6S

PRODUCTS

生成物

1
结构：CC(C)Nc1c([N+](=O)[O-])cc(C(=O)O)cc1S(N)(=O)=O
HCID21506011

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Isopropylamine (120 ml) and water 8 ml) were added to 4-chloro-3-nitro-5-sulphamyl-benzoic acid (22.4 g), while cooling. Then the reaction mixture was stirred for 5 days at room temperature. After evaporation in vacuo, the residue was triturated with 4N hydrochloric acid, after which the resulting 4-isopropylamino-3-nitro-5-sulphamyl-benzoic acid was collected by suction. After recrystallization from aqueous ethanol, the acid was obtained with a melting point of 206°C (decomp.).

WORKUP

后处理

  1. temperaturewhile cooling
  2. customAfter evaporation in vacuo
  3. customthe residue was triturated with 4N hydrochloric acid
  4. customafter which the resulting 4-isopropylamino-3-nitro-5-sulphamyl-benzoic acid was collected by suction
  5. customAfter recrystallization from aqueous ethanol
  6. customthe acid was obtained with a melting point of 206°C (decomp.)