Isopropylamine → 4-Isopropylamino-3-nitro-5-sulphamyl-benzoic acid

Participants

Reaction Steps

Isopropylamine (120 ml) and water 8 ml) were added to 4-chloro-3-nitro-5-sulphamyl-benzoic acid (22.4 g), while cooling. Then the reaction mixture was stirred for 5 days at room temperature. After evaporation in vacuo, the residue was triturated with 4N hydrochloric acid, after which the resulting 4-isopropylamino-3-nitro-5-sulphamyl-benzoic acid was collected by suction. After recrystallization from aqueous ethanol, the acid was obtained with a melting point of 206°C (decomp.).

Provenance & Evidence