HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1287744Generated: October 31, 2026
Hydrochloric Acid → 3-Nitro-4-piperidino-5-sulphamyl-benzoic acid
https://huagongshe.com/reaction/1287744
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Chloro-3-nitro-5-sulphamoylbenzoic acid | HCID 89893 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Nitro-4-piperidino-5-sulphamyl-benzoic acid | HCID 21506107 | — |
Reaction Steps
A mixture of 4-chloro-3-nitro-5-sulphamyl-benzoic acid (2.8 g), piperidine (3.4 g), and water (13 ml) was stirred at 95° C for 2 hours. Then the reaction mixture was adjusted to a pH of 2.5 by the addition of 4N hydrochloric acid, and the precipitated 3-nitro-4-piperidino-5-sulphamyl-benzoic acid was collected and recrystallized from aqueous methanol. The melting point was 237°-238° C (decomp.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03985777 |
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| Source dataset | uspto-grants-1976_10 |
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| ORD ID | ord-b84dd694674f474d801c0d7e51eb80a7 |
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| Source note | uspto-grants-1976_10 |
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