反应详情

温度

95 °C

A mixture of 4-chloro-3-nitro-5-sulphamyl-benzoic acid (2.8 g), piperidine (3.4 g), and water (13 ml) was stirred at 95° C for 2 hours. Then the reaction mixture was adjusted to a pH of 2.5 by the addition of 4N hydrochloric acid, and the precipitated 3-nitro-4-piperidino-5-sulphamyl-benzoic acid was collected and recrystallized from aqueous methanol. The melting point was 237°-238° C (decomp.)

1. customthe precipitated 3-nitro-4-piperidino-5-sulphamyl-benzoic acid was collected
2. customrecrystallized from aqueous methanol