Lactic Acid → HCID 21506579, compound

HRID 1287823Notes

Reaction equation

HRID 1287823 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH2:12])[CH:5]=[CH:4][CH:3]=1.[C:13](O)(=O)[CH:14]([CH3:16])[OH:15]>Cl>[CH3:13][CH:14]([C:16]1[NH:1][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[C:11]=2[C:10]([N:12]=1)=[CH:9][CH:8]=[CH:7]3)[OH:15]

Participants

4

Reactant 2

HCID 612Lactic AcidHCID 680671,8-Diaminonaphthalene

Product 1

HCID 21506579HCID 21506579, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 32 g (0.2 mole) of 1,8-diaminonaphthalene and 32 g (0.3 mole) of 85% lactic acid in 400 ml of 4N hydrochloric acid is refluxed for 18 hr. The separated solid is filtered and converted to the free base by treatment with dilute ammonia for 2 hr. The new solid is filtered and recrystallized twice from 95% ethanol to give the product, α-methyl-2-perimidinemethanol, as yellow crystals, m.p. 205°-206° dec.

Workup

  1. temperatureis refluxed for 18 hr
  2. filtrationThe separated solid is filtered
  3. filtrationThe new solid is filtered
  4. customrecrystallized twice from 95% ethanol

Sources & evidence

ORD record
ord-d625bd56b8c6485e9eebb46e5e1cb8bf
Source dataset
uspto-grants-1976_10
Patent number
US03985880

Reaction notes

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