反应详情

2-Amino-4-nitrobenzenethiol, 9.6 g (0.054 mole) and thiophene-2-carboxylic acid, 10.0 g (0.075 mole) are added to a solution of 54 g of PPE in 130 cc CHCl3. The mixture is heated at reflux for 2 hours. It is then concentrated in vacuo and the residue poured over ice. The pH is adjusted to 10 with 50% NaOH solution, and the precipitate filtered and washed with H2O. Drying in vacuo yields 15 g of the title compound.

1. temperatureThe mixture is heated
2. temperatureat reflux for 2 hours
3. concentrationIt is then concentrated in vacuo
4. additionthe residue poured over ice
5. filtrationthe precipitate filtered
6. washwashed with H2O
7. customDrying in vacuo