2-Thiophenecarboxylic acid → 5-Nitro-2-(thiophen-2-yl)-1,3-benzothiazole

Beteiligte Stoffe

Reaktionsschritte

2-Amino-4-nitrobenzenethiol, 9.6 g (0.054 mole) and thiophene-2-carboxylic acid, 10.0 g (0.075 mole) are added to a solution of 54 g of PPE in 130 cc CHCl3. The mixture is heated at reflux for 2 hours. It is then concentrated in vacuo and the residue poured over ice. The pH is adjusted to 10 with 50% NaOH solution, and the precipitate filtered and washed with H2O. Drying in vacuo yields 15 g of the title compound.

Herkunft & Nachweise