Isopropanol → HCID 21506796, compound

HRID 1287856Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]2[C:16](=[CH:17][CH:18]=1)[C:8]1([CH2:13][CH2:12][C:11](=[O:14])[NH:10][C:9]1=[O:15])[CH2:7][CH2:6][C:5]2=[O:19].[CH:20](O)(C)C>>[CH3:20][N:10]1[C:11](=[O:14])[CH2:12][CH2:13][C:8]2([C:16]3[C:4](=[CH:3][C:2]([CH3:1])=[CH:18][CH:17]=3)[C:5](=[O:19])[CH2:6][CH2:7]2)[C:9]1=[O:15]

Participants

Reactant 2

HCID 3776Isopropanol

HCID 21506790HCID 21506790, compound

Product 1

HCID 21506796HCID 21506796, compoundYield 80%

Procedure

Following the procedure noted in Example 5, 38.6 grams (0.15 M) of 2,3-dihydro-6-methylspiro-[naphthalene-1(4H),3'-piperidine]-2',4,6'-trione was methylated to give 32.5 grams (80%) of 1',6-dimethyl-2,3-dihydrospiro-[naphthalene-1(4H),3'-piperidine]-2',4,6'-trione, melting point 146°-147.5° C. from isopropyl alcohol.

Sources & evidence

ORD record: ord-2c86746d64a34e9fa19c8f05695fb675
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03985888

Reaction notes

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