1-Methyl-4-piperidone → 4-(4-Chloro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine

HRID 1287914Notes

Reaction equation

HRID 1287914 reaction equation
Br[C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[CH3:11][N:12]1[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]1>>[Cl:10][C:8]1[CH:7]=[CH:6][C:3]([CH2:4][OH:5])=[C:2]([C:15]2([OH:18])[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)[CH:9]=1

Participants

3

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 54049764(2-Bromo-4-chlorophenyl)methanol

Product 1

HCID 867335284-(4-Chloro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine

Procedure

Reaction of 2-bromo-4-chlorobenzyl alcohol and 1-methyl-4-piperidone by the method described in Example 16a provides 4-(4-chloro-α-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine.

Sources & evidence

ORD record
ord-18f217f0c2c049f6b3a33471238578e6
Source dataset
uspto-grants-1976_10
Patent number
US03985889

Reaction notes

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