1-Methyl-4-piperidone → 4-(5-Fluoro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine

HRID 1287916Notes

Reaction equation

HRID 1287916 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH2:4][OH:5].[CH3:11][N:12]1[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]1>>[F:10][C:7]1[CH:8]=[CH:9][C:2]([C:15]2([OH:18])[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)=[C:3]([CH2:4][OH:5])[CH:6]=1

Participants

3

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 27733492-Bromo-5-fluorobenzyl alcohol

Product 1

HCID 867335294-(5-Fluoro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine

Procedure

Reaction of 2-bromo-5-fluorobenzyl alcohol and 1-methyl-4-piperidone by the method described in Example 16a provides 4-(5-fluoro-α-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine.

Sources & evidence

ORD record
ord-016545b9194445e7b8a7d920a8cc1b42
Source dataset
uspto-grants-1976_10
Patent number
US03985889

Reaction notes

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