HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-piperidone → 4-(5-Fluoro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Reactant | 2-Bromo-5-fluorobenzyl alcohol | HCID 2773349 | — |
| Product | 4-(5-Fluoro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine | HCID 86733529 | — |
Reaction Steps
Reaction of 2-bromo-5-fluorobenzyl alcohol and 1-methyl-4-piperidone by the method described in Example 16a provides 4-(5-fluoro-α-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03985889 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-016545b9194445e7b8a7d920a8cc1b42 |
| Source note | uspto-grants-1976_10 |