Aluminium lithium hydride → HCID 19917663, compound

HRID 1287983Notes

Reaction equation

HRID 1287983 reaction equation
C([O:3][C:4]([CH2:6][CH:7]1[CH2:12][CH:11]2[CH2:13][CH2:14][N:8]1[CH2:9][CH2:10]2)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[OH:3][CH2:4][CH2:6][CH:7]1[CH2:12][CH:11]2[CH2:10][CH2:9][N:8]1[CH2:14][CH2:13]2

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21503370HCID 21503370, compound

Product 1

HCID 19917663HCID 19917663, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

15.9 g of 2-ethoxycarbonylmethyl-quinuclidine were reduced with lithium aluminium hydride in the presence of ether under reflux to give 12.3 g of 2-hydroxyethylquinuclidine, m.p. 62°-64° C.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-faa271a377844fd8aeff5400a4719516
Source dataset
uspto-grants-1976_10
Patent number
US03987042

Reaction notes

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