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O-Toluidine → 1-Methyl-N-(2-methylphenyl)cyclohexane-1-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Toluidine | HCID 7242 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Methylcyclohexanecarbonyl chloride | HCID 4189245 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Methyl-N-(2-methylphenyl)cyclohexane-1-carboxamide | HCID 12751648 | — |
反応手順
A mixture of 32.7 grams (0.203 moles) of 1-methyl-1-cyclohexanecarboxylic acid chloride, 15.2 grams (0.11 mole) of anhydrous potassium carbonate and 21.8 grams (0.203 mole) of o-toluidine in 260 ml. of dry toluene is stirred and refluxed for 2.5 hours. The inorganic salts are removed by filtration and the filtrate is concentrated in vacuuo. The residue yields from diethyl ether-pentane 40.5 grams (87%) of N-(1-methylcyclohexyl carbonyl)-o-toluidine; m.p. 138° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03987059 |
| 出典データセット | uspto-grants-1976_10 |
| ORD ID | ord-e549e00b74e4479fa38b5559650dafbe |
| 出典メモ | uspto-grants-1976_10 |