O-Toluidine → 1-Methyl-N-(2-methylphenyl)cyclohexane-1-carboxamide

HRID 1288042노트

반응식

HRID 1288042 반응식
[CH3:1][C:2]1([C:8](Cl)=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].[NH2:17][C:18]1[C:19]([CH3:24])=[CH:20][CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1([C:8]([NH:17][C:18]2[C:19]([CH3:24])=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 7242O-ToluidineHCID 11430Potassium CarbonateHCID 41892451-Methylcyclohexanecarbonyl chloride

생성물 1

HCID 127516481-Methyl-N-(2-methylphenyl)cyclohexane-1-carboxamide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 32.7 grams (0.203 moles) of 1-methyl-1-cyclohexanecarboxylic acid chloride, 15.2 grams (0.11 mole) of anhydrous potassium carbonate and 21.8 grams (0.203 mole) of o-toluidine in 260 ml. of dry toluene is stirred and refluxed for 2.5 hours. The inorganic salts are removed by filtration and the filtrate is concentrated in vacuuo. The residue yields from diethyl ether-pentane 40.5 grams (87%) of N-(1-methylcyclohexyl carbonyl)-o-toluidine; m.p. 138° C.

후처리

  1. temperaturerefluxed for 2.5 hours
  2. customThe inorganic salts are removed by filtration
  3. concentrationthe filtrate is concentrated in vacuuo

출처 및 근거

ORD 기록
ord-e549e00b74e4479fa38b5559650dafbe
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987059

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