Benzoylhydrazine → HCID 21489334, compound

HRID 1288050Notes

Reaction equation

HRID 1288050 reaction equation
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=S)[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:7]=2[CH:21]=1)[CH3:2].[C:22]([NH:30][NH2:31])(=O)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(O)C>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:22]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[N:30][N:31]=[C:11]3[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:7]=2[CH:21]=1)[CH3:2]

Participants

4

Reactant 2

HCID 11955BenzoylhydrazineHCID 21503711HCID 21503711, compound

Product 1

HCID 21489334HCID 21489334, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 7-ethyl-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione is heated in ethanol with benzoic acid hydrazide and the resulting product heated to 250° C. to give 8-ethyl-1-phenyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-f4cd2244407f44bbbb59fca6b69f1936
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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