Acetohydrazide → HCID 21489308, compound

HRID 1288057Notes

Reaction equation

HRID 1288057 reaction equation
[Cl:1][C:2]1[C:7]2[C:8]([C:14]3[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=3)=[N:9][CH2:10][C:11](=S)[NH:12][C:6]=2[C:5]([Cl:23])=[CH:4][CH:3]=1.[C:24]([NH:27][NH2:28])(=O)[CH3:25]>C(O)C>[Cl:1][C:2]1[C:7]2[C:8]([C:14]3[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=3)=[N:9][CH2:10][C:11]3[N:12]([C:24]([CH3:25])=[N:27][N:28]=3)[C:6]=2[C:5]([Cl:23])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 19865807HCID 19865807, compound

Product 1

HCID 21489308HCID 21489308, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 6,9-dichloro-1,3-dihydro-5-(p-isopropylphenyl)-2H-1,4-benzodiazepine-2-thione is heated in ethanol with acetic acid hydrazide and the resulting product heated to 250° C. to give 7,10-dichloro-1-methyl-6-(p-isopropylphenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-93e960a7975a4d9c9a384a828026f222
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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