Propionylhydrazine → HCID 21489340, compound

HRID 1288059Notes

Reaction equation

HRID 1288059 reaction equation
[CH2:1]([S:4]([C:7]1[C:17]2[NH:16][C:15](=S)[CH2:14][N:13]=[C:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2[CH:10]=[C:9]([CH3:25])[CH:8]=1)(=[O:6])=[O:5])[CH2:2][CH3:3].[C:26]([NH:30][NH2:31])(=O)[CH2:27][CH3:28]>C(O)C>[CH2:1]([S:4]([C:7]1[C:17]2[N:16]3[C:26]([CH2:27][CH3:28])=[N:30][N:31]=[C:15]3[CH2:14][N:13]=[C:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2[CH:10]=[C:9]([CH3:25])[CH:8]=1)(=[O:6])=[O:5])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 79890PropionylhydrazineHCID 19865840HCID 19865840, compound

Product 1

HCID 21489340HCID 21489340, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 9-(propylsulfonyl)-7-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione is heated in ethanol with propionic acid hydrazide and the resulting product heated to 250° C. to give 10-(propylsulfonyl)-8-methyl-1-ethyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-ca30cdbefd104ac78749255ed773c04d
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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