4-Chlorobenzoyl chloride → 3-(p-Chloro-benzoyl)-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline

HRID 1288146Notes

Reaction equation

HRID 1288146 reaction equation
[CH3:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:3]=12.[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>N1C=CC=CC=1>[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([N:14]2[CH2:15][CH2:16][C:3]3[C:4](=[N:5][C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=4[C:2]=3[CH3:1])[CH2:12][CH2:13]2)=[O:23])=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 304399911-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]quinoline

Product 1

HCID 215036113-(p-Chloro-benzoyl)-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinolineYield 65%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-(p-Chloro-benzoyl)-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline was prepared from 1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline and 4-chloro-benzoyl chloride in pyridine.

Sources & evidence

ORD record
ord-689b519ae90946a6bba4eb359b25e317
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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