Hydrochloric Acid → 11-Methyl-2,3,4,5-tetrahydro-1H-azepino[4,3-b]quinolin-5-ol--hydrogen chloride (1/2)

HRID 1288156Notes

Reaction equation

C(OC([N:6]1[CH2:21][CH2:20][CH:19]([O:22]C(OCC)=O)[C:9]2=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]([CH3:18])=[C:8]2[CH2:7]1)=O)C.[ClH:28]>>[ClH:28].[ClH:28].[OH:22][CH:19]1[C:9]2=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]([CH3:18])=[C:8]2[CH2:7][NH:6][CH2:21][CH2:20]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 54415347HCID 54415347, compound

Product 1

HCID 304401111-Methyl-2,3,4,5-tetrahydro-1H-azepino[4,3-b]quinolin-5-ol--hydrogen chloride (1/2)Yield 70%

Procedure

2,3,4,5-Tetrahydro-5-hydroxy-11-methyl-1H-azepino[4,3-b]quinoline dihydrochloride was prepared from 5-(ethoxy-carbonyloxy)-2,3,4,5-tetrahydro-11-methyl-1H-2-azepino[4,3-b]quinoline-carboxylic acid ethyl ester by hydrolysis with 2 N hydrochloric acid.

Sources & evidence

ORD record: ord-0ac794b1f1b84c0ab36193348fd8312d
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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