Sodium ethoxide → HCID 21503525, compound

HRID 1288169Notes

Reaction equation

HRID 1288169 reaction equation
C(OC([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH:8](Cl)[CH2:7]1)=O)C.[O-]CC.[Na+]>C(O)C>[CH3:21][C:17]1[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N:10]=[C:9]2[CH:8]=[CH:7][NH:6][CH2:20][CH2:19][C:18]=12

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 54025343HCID 54025343, compound

Product 1

HCID 21503525HCID 21503525, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3 gm (5.42 millimols) of 5-chloro-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester, 45 millimols of sodium ethoxide and 150 ml of ethanol was boiled for 2 hours. After distilling off the ethanol, the residue was dissolved in water, the solution was extracted with chloroform, the extract was dried with sodium sulfate, the solvent was evaporated, and the residue was recrystallized from ether.

Workup

  1. distillationAfter distilling off the ethanol
  2. dissolutionthe residue was dissolved in water
  3. extractionthe solution was extracted with chloroform
  4. dry with materialthe extract was dried with sodium sulfate
  5. customthe solvent was evaporated
  6. customthe residue was recrystallized from ether

Sources & evidence

ORD record
ord-760affd583a44a6aa0922acbdbf17777
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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