Pyrrolidine → 1,2,4,5-Tetrahydro-11-pyrrolidino-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester

HRID 1288188Notes

Reaction equation

HRID 1288188 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2Cl)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[NH:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[N:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 2150364411-chloro-3-ethoxycarbonyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline

Product 1

HCID 537297051,2,4,5-Tetrahydro-11-pyrrolidino-3-azepino[4,5-b]quinoline-carboxylic acid ethyl esterYield 18%

Procedure

1,2,4,5-Tetrahydro-11-pyrrolidino-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester was prepared from 1,2,4,5-tetrahydro-11-chloro-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester and pyrrolidine analogous to Example 204.

Sources & evidence

ORD record
ord-39af49ca4d8f4ca5b2b6593d41016697
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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