Ethyl chloroformate → HCID 178473335, compound

HRID 1288196Notes

Reaction equation

C([N:8]1[CH2:23][CH2:22][CH2:21][C:11]2=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:19]([OH:20])=[C:10]2[CH2:9]1)C1C=CC=CC=1.Cl[C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[CH2:28]([O:27][C:25]([N:8]1[CH2:23][CH2:22][CH2:21][C:11]2=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:19]([OH:20])=[C:10]2[CH2:9]1)=[O:26])[CH3:29]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 178515156HCID 178515156, compound

Product 1

HCID 178473335HCID 178473335, compoundYield 9%

Procedure

11-Hydroxy-2,3,4,5-tetrahydro-1H-2-azepino[4,3-b]quinoline-carboxylic acid ethyl ester was prepared from 2-benzyl-11-hydroxy-2,3,4,5-tetrahydro-1H-azepino[4,3-b]quinoline and ethyl chloroformate analogous to Example 208. Yield: 9% of theory; m.p. 285° C.

Sources & evidence

ORD record: ord-e3bd3fc398714bf3a1e5b44f957f50d3
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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