Phenacylamine → HCID 21503631, compound

HRID 1288197Notes

Reaction equation

HRID 1288197 reaction equation
C(O[C:4]1[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][CH2:12][CH3:13])[CH2:6][CH:5]=1)C.N[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=O.C1(N)C(F)=C(F)C(F)=C([NH2:33])C=1F.Cl.Cl>>[CH3:15][C:16]1[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:33]=[C:4]2[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][CH2:12][CH3:13])[CH2:6][C:5]=12

Participants

4

Reactant 3

HCID 11952PhenacylamineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride2×HCID 21503526HCID 21503526, compound

Product 1

HCID 21503631HCID 21503631, compound

Procedure

2,3,4,5-tetrahydro-11-methyl-2-propyl-1H-azepino[4,3-b]quinoline and their dihydrochlorides were prepared from 4-ethoxy-1,2,6,7-tetrahydro-1-propyl-5H-azepine and 2amino-acetophenone analogous to Example 217. Yield of the dihydrochloride of the [4,5-b]-isomer: 15% of theory; m.p. 245-246° C. Yield of the dihydrochloride of the [4,3-b]-isomer: 10% of theory; m.p. 282° C.

Sources & evidence

ORD record
ord-c47206e8528548f89207aeffa16a4806
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

Loading…