Ethyl chloroformate → HCID 53684965, compound

HRID 1288199Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]([CH3:17])=[C:7]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12][C:8]3=[N:9][C:10]=2[CH:11]=1.Cl[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[CH2:22]([O:21][C:19]([N:14]1[CH2:15][CH2:16][C:7]2[C:8](=[N:9][C:10]3[CH:11]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=3[C:6]=2[CH3:17])[CH2:12][CH2:13]1)=[O:20])[CH3:23]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 21503414HCID 21503414, compound

Product 1

HCID 53684965HCID 53684965, compoundYield 79%

Procedure

8,11-Dimethyl-1,2,4,5-tetrahydro-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester was prepared from 8,11-dimethyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline and ethyl chloroformate analogous to Example 155. Yield: 79% of theory; m.p. 121° C.

Sources & evidence

ORD record: ord-c5cc336f6a9740ad8c2a9dd1194e2f78
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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