11-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]quinoline → 3-Carbamoyl-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline

HRID 1288204Notes

Reaction equation

HRID 1288204 reaction equation
[CH3:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:3]=12.[O-:17][C:18]#[N:19].[K+]>O>[C:18]([N:14]1[CH2:15][CH2:16][C:3]2[C:4](=[N:5][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=3[C:2]=2[CH3:1])[CH2:12][CH2:13]1)(=[O:17])[NH2:19]

Participants

4

Reactant 2

HCID 304399911-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]quinolineHCID 11378442Potassium cyanate

Product 1

HCID 215036673-Carbamoyl-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.3 gm (11.6 millimols) of 1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline were reacted with 0.04 gm (11.6 millimols) of potassium cyanate at room temperature in 50 ml of water. After 4 to 6 hours, the reaction product crystallized out. Yield: 1 gm (34% of theory); m.p. 215° C (decomp.).

Workup

  1. customthe reaction product crystallized out

Sources & evidence

ORD record
ord-8e0616792a9f4887b08ff0f6ca083dea
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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