反应详情

A solution of 2-phenoxypropionitrile (11.0 s.) in dry ether (50 ml.) was added dropwise to a stirred suspension of lithium aluminium hydride (3.8 g.) in dry ether (50 ml.). The mixture was then heated to reflux for 3 hours, cooled and treated cautiously (vigorous stirring) with water (3.8 ml.) then with 15% aqueous sodium hydroxide (3.8 ml.) and finally with water (11.4 ml.). The mixture was stirred for 20 minutes and filtered. The filtrate was dried over anhydrous potassium carbonate and evaporated. The residue was distilled under water-pump vacuum to give pure 2-phenoxypropylamine, b.p. 115°-116°/15 mm.

1. temperatureThe mixture was then heated
2. temperatureto reflux for 3 hours
3. temperaturecooled
4. additiontreated cautiously
5. filtrationfiltered
6. dry with materialThe filtrate was dried over anhydrous potassium carbonate
7. customevaporated
8. distillationThe residue was distilled under water-pump vacuum