反应详情

A mixture of 3-bromobutan-2-one (75.5 g.) and finely-powdered potassium iodide (1 g.) in ethyl methyl ketone (50 ml.) was added dropwise, over 25 minutes, to a stirred, refluxing mixture of phenol (47 g.) and dry potassium carbonate (82 g.) in ethyl methyl ketone (100 ml.) Stirring and refluxing were continued for a total of 5 hours and the mixture was cooled, poured into water (cs. 500 ml.) and extracted with ether. The ether extract was washed exhaustively with 5N-sodium hydroxide, dried over anhydrous sodium sulphate and evaporated. The residue was distilled to give pure 3-phenoxybutan-2-one, b.p. 110°-112°/14 mm.

1. additionwas added dropwise, over 25 minutes, to a stirred
2. temperaturerefluxing
3. temperaturerefluxing
4. customwere continued for a total of 5 hours
5. temperaturethe mixture was cooled
6. extractionextracted with ether
7. extractionThe ether extract
8. washwas washed exhaustively with 5N-sodium hydroxide
9. dry with materialdried over anhydrous sodium sulphate
10. customevaporated
11. distillationThe residue was distilled