反应详情

2-Allyloxybenzamidine hydrochloride (10.2 g.) was added to a solution of sodium (4.6 g.) in anhydrous methanol (200 ml.) with stirring, followed by ethyl α-oximinocyanoacetate (7.6 g.), and the mixture was stirred under reflux for 6 hours. The hot mixture was poured into water (500 ml.) and acidified with glacial acetic acid. The blue solid was filtered off, washed with water and recrystallised from 50% aqueous acetic acid to give 2-(2-allyloxyphenyl)-4-amino-5-nitrosopyrimid-6-one (7.3 g.), m.p. 217°-220° C.

1. stirringthe mixture was stirred
2. temperatureunder reflux for 6 hours
3. filtrationThe blue solid was filtered off
4. washwashed with water
5. customrecrystallised from 50% aqueous acetic acid