Sodium Dithionite → 4,5-Diamino-2-benzylpyrimid-6-one

참여 물질

반응 조건

반응 단계

Sodium dithionite (30 g.) was added in portions to an agitated suspension of 4-amino-2-benzyl-5-phenylazo-pyrimid-6-one (14 g.) in a mixture of ethanol (200 ml.) and 2N aqueous sodium hydroxide solution (200 ml.) maintained at a temperature near to the reflux temperature. The mixture was then heated under reflux for 20 minutes, treated with a further quantity of sodium dithionite (20 g.) and the mixture heated under reflux for a further 30 minutes. The mixture was then evaporated to dryness, the residue was dissolved in water (200 ml.), acidified to pH 6 by means of concentrated hydrochloric acid, cooled to 0° C, and filtered. The solid thus obtained was recrystallised from water to give 4,5-diamino-2-benzyl-pyrimid-6-one (4.4 g.), m.p. 243°-246° C.

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