Sodium → HCID 136144774, compound

HRID 1288281Notes

Reaction equation

HRID 1288281 reaction equation
[Na].[NH2:2][C:3]1[N:4]=[C:5]([CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[NH:6][C:7](=[O:11])[C:8]=1[N:9]=O>O>[NH2:2][C:3]1[N:4]=[C:5]([CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[NH:6][C:7](=[O:11])[C:8]=1[NH2:9]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 136062367HCID 136062367, compound

Product 1

HCID 136144774HCID 136144774, compoundYield 20.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Crude sodium salt of 4-amino-5-nitroso-2-(2-phenylethyl)pyrimid-6-one (3.8 g.) was dissolved in water (5.5 ml.). A trace of insoluble material was filtered off, and sodium dithionite (4.08 g.) was added slowly to the filtrate with stirring. The solid which separated was filtered off, washed with water, and recrystallised from ethanol to give 4,5-diamino-2-(2-phenylethyl)pyrimid-6-one (0.75 g.), m.p. 204°-206° C. (with decomposition).

Workup

  1. filtrationA trace of insoluble material was filtered off
  2. additionsodium dithionite (4.08 g.) was added slowly to the filtrate
  3. customThe solid which separated
  4. filtrationwas filtered off
  5. washwashed with water
  6. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-3d775f1879614cfaaeb2d2ad835e3cee
Source dataset
uspto-grants-1976_10
Patent number
US03987160

Reaction notes

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