Sodium Dithionite → HCID 136354628, compound

HRID 1288301Notes

Reaction equation

HRID 1288301 reaction equation
S(S([O-])=O)([O-])=O.[Na+].[Na+].[Na].[NH2:10][C:11]1[N:12]=[C:13]([C:20]2[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=2[O:27][CH2:28][CH2:29][CH3:30])[NH:14][C:15](=[O:19])[C:16]=1[N:17]=O>O>[NH2:10][C:11]1[N:12]=[C:13]([C:20]2[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=2[O:27][CH2:28][CH2:29][CH3:30])[NH:14][C:15](=[O:19])[C:16]=1[NH2:17]

Participants

5

Reactant 3

HCID 24489Sodium DithioniteHCID 5360545SodiumHCID 136354629HCID 136354629, compound

Product 1

HCID 136354628HCID 136354628, compoundYield 55.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium dithionite (10.8 g.) was added during 5 minutes to a stirred suspension of the crude sodium salt of 4-amino-2-(5-methyl-2-propoxyphenyl)-5-nitrosopyrimid-6-one (9.3 g.) in water (180 ml.). Stirring was continued for a further 105 minutes, and solid obtained was filtered off, washed with water, and recrystallised from aqueous ethanol to give 4,5-diamino-2-(5-methyl-2-propoxyphenyl)pyrimid-6-one (4.9 g.), m.p. 184°-188° C. (with decomposition).

Workup

  1. customsolid obtained
  2. filtrationwas filtered off
  3. washwashed with water
  4. customrecrystallised from aqueous ethanol

Sources & evidence

ORD record
ord-249be4e3739a423eab8a087ec3624e20
Source dataset
uspto-grants-1976_10
Patent number
US03987160

Reaction notes

Loading…