Methylamine → HCID 14943551, compound

HRID 128834Notes

Reaction equation

HRID 128834 reaction equation
Cl[C:2]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH:5]=1)=[O:3].[CH3:22][NH2:23]>>[CH2:22]([NH:23][C:2]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH:5]=1)=[O:3])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 27762111-(Benzenesulfonyl)-1H-indole-3-carbonyl chloride

Product 1

HCID 14943551HCID 14943551, compound

Procedure

Reaction of 3-chlorocarbonyl-1-(phenylsulfonyl)indole [XXIII] with an excess of methylamine as above gave N-methyl-1-(phenylsulfonyl)indole-3-carboxamide [XXIV: R8 =Me]; mp (MeOH) 192.5°-195° C.

Sources & evidence

ORD record
ord-f334b9063fcb4493aa08074c1623a03c
Source dataset
uspto-grants-1995_11
Patent number
US05464861

Reaction notes

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