反应详情

The synthesis of this compound is carried out as described in Example 2 except that, in Step A, the acetic anhydride is replaced by an equimolar amount of chloroacetic anhydride. The product of Step A is ethyl 7-(2-chloroacetamido)heptanoate. Subsequent steps yield: ethyl 7-[N-(4-acetoxynonyl)-2-chloroacetamido] heptanoate (B); and 7-[N-(4-hydroxynonyl-2-hydroxyacetamido]-heptanoic acid (C); (the basic hydrolytic conditions cause the replacement of the chlorine atom by hydroxy in this step).

1. customThe synthesis of this compound