HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 7-[N-(4-Hydroxynonyl)-2-hydroxyacetamido]-heptanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Chloroacetic anhydride | HCID 10946 | — |
| Reactant | 7-[N-(4-hydroxynonyl)acrylamido]heptanoic acid | HCID 21503936 | — |
| Reactant | ethyl 7-[N-(4-acetoxynonyl)-acrylamido]heptanoate | HCID 21503957 | — |
| Reactant | Ethyl 7-(2-chloroacetamido)heptanoate | HCID 21503969 | — |
| Product | 7-[N-(4-Hydroxynonyl)-2-hydroxyacetamido]-heptanoic acid | HCID 21503974 | — |
Reaction Steps
The synthesis of this compound is carried out as described in Example 2 except that, in Step A, the acetic anhydride is replaced by an equimolar amount of chloroacetic anhydride. The product of Step A is ethyl 7-(2-chloroacetamido)heptanoate. Subsequent steps yield: ethyl 7-[N-(4-acetoxynonyl)-2-chloroacetamido] heptanoate (B); and 7-[N-(4-hydroxynonyl-2-hydroxyacetamido]-heptanoic acid (C); (the basic hydrolytic conditions cause the replacement of the chlorine atom by hydroxy in this step).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03987091 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-26c767adee8149eeb97b477e9dc2b7cd |
| Source note | uspto-grants-1976_10 |