2-Chloro-4-nitrobenzoic acid → 4-Chlorophenyl 2-chloro-4-nitrophenyl ketone

HRID 1288409Notes

Reaction equation

HRID 1288409 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:8][C:9]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=O>C1C=CC=CC=1>[Cl:8][C:9]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:10]=1[C:11]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:13]

Participants

4

Reactant 2

HCID 74482-Chloro-4-nitrobenzoic acidHCID 7964Chlorobenzene

Product 1

HCID 8862964-Chlorophenyl 2-chloro-4-nitrophenyl ketoneYield 50%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Repeating Example 21 in every detail except that a chlorobenzene solution of 2-chloro-4-nitrobenzoic acid was employed in lieu of the benzene solution of the same, there is obtained a 50% yield of 2,4'-dichloro-4-nitrobenzophenone in good yield and purity having a melting point of 117° - 117.5° C.

Sources & evidence

ORD record
ord-596521e18626411fac269b32946eda6e
Source dataset
uspto-grants-1976_10
Patent number
US03988300

Reaction notes

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