Aspirin → 29825-08-9

HRID 1288428Notes

Reaction equation

C([Al:5](CC(C)C)CC(C)C)C(C)C.[C:14]([O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([OH:22])=[O:21])(=[O:16])[CH3:15]>O1CCCC1>[C:14]([O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([O-:22])=[O:21])(=[O:16])[CH3:15].[C:14]([O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([O-:22])=[O:21])(=[O:16])[CH3:15].[C:14]([O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([O-:22])=[O:21])(=[O:16])[CH3:15].[Al+3:5]

Participants

Conditions

Temperature: 0 °C

Procedure

3.96 g of tri-isobutyl aluminum were added into 50 ml of tetrahydrofuran and the solution was cooled to 0° C. under nitrogen gas current, a solution of 10.8 g of o-acetoxybenzoic acid dissolved in 100 ml of tetrahydrofuran was added dropwise little by little to the above solution. After completion of the dropwise addition, the reaction mixture was treated in the same manner as in Example 5, followed by drying under reduced pressure. Thus, 10 g of white aluminum tris-(o-acetoxybenzoate) were obtained. The resulting aluminum salt had a molecular weight of about 570, and the average degree of polymerization was found to be about 1. The infrared absorption spectrum of the salt was as follows:

Workup

additionwas added dropwise little by little to the above solution
additionAfter completion of the dropwise addition
additionthe reaction mixture was treated in the same manner as in Example 5
customby drying under reduced pressure

Sources & evidence

ORD record: ord-49ecb359716c4554bb756c987dc52d18
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03988333

Reaction notes

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