HCID 21393798, compound → HCID 21393827, compound

HRID 1288458Notes

Reaction equation

HRID 1288458 reaction equation
[H][H].Cl.C([NH:7][C:8]1[C:9]([Cl:18])=[CH:10][CH:11]=[C:12]2[C:17]=1[CH:16]=[N:15][CH:14]=[CH:13]2)(=O)C>CO.[Pt]=O>[ClH:18].[NH2:7][C:8]1[C:9]([Cl:18])=[CH:10][CH:11]=[C:12]2[C:17]=1[CH2:16][NH:15][CH2:14][CH2:13]2

Participants

5

Reactant 2

HCID 21393798HCID 21393798, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21393827HCID 21393827, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Platinum oxide (0.1 g.) in methanol is reduced with hydrogen at atmospheric pressure. 8-Acetamido-7-chloroisoquinoline hydrochloride (1.0 g.) is treated as in Example 11 to give 8-amino-7-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride.

Sources & evidence

ORD record
ord-9c3e33916a154c1882106c0502ca9806
Source dataset
uspto-grants-1976_10
Patent number
US03988339

Reaction notes

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