HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Acetamido-7-chloroisoquinoline hydrochloride → 8-Amino-7-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Acetamido-7-chloroisoquinoline hydrochloride | HCID 21393798 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-Amino-7-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 21393827 | — |
Reaction Steps
Platinum oxide (0.1 g.) in methanol is reduced with hydrogen at atmospheric pressure. 8-Acetamido-7-chloroisoquinoline hydrochloride (1.0 g.) is treated as in Example 11 to give 8-amino-7-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03988339 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-9c3e33916a154c1882106c0502ca9806 |
| Source note | uspto-grants-1976_10 |