Acetic Acid → HCID 21393852, compound

HRID 1288466Notes

Reaction equation

HRID 1288466 reaction equation
[N+:1]([C:4]1[C:5]([C:14]([F:17])([F:16])[F:15])=[CH:6][CH:7]=[C:8]2[C:13]=1[CH:12]=[N:11][CH:10]=[CH:9]2)([O-])=O.C(O)(=O)C.[OH-].[NH4+]>C(O)C.O.[Zn]>[NH2:1][C:4]1[C:5]([C:14]([F:17])([F:15])[F:16])=[CH:6][CH:7]=[C:8]2[C:13]=1[CH:12]=[N:11][CH:10]=[CH:9]2

Participants

7

Reactant 3

HCID 176Acetic AcidHCID 14923Ammonium HydroxideHCID 21393813HCID 21393813, compound

Product 1

HCID 21393852HCID 21393852, compound

Reagents, catalysts & solvents 3

HCID 23994ZincCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

According to the procedure in Example 12, 8-nitro-7-trifluoromethylisoquinoline is heated with zinc and acetic acid in ethanol and water on a steam bath for five minutes and the reaction mixture is cooled, made alkaline and aqueous ammonium hydroxide and extracted with ethyl acetate. Removing the solvent from the extract in vacuo gives, as the residue, 8-amino-7-trifluoromethylisoquinoline.

Workup

  1. temperaturethe reaction mixture is cooled
  2. extractionextracted with ethyl acetate
  3. customRemoving the solvent from the
  4. extractionextract in vacuo

Sources & evidence

ORD record
ord-d74fac94050c4c9a90c832d873f9f64f
Source dataset
uspto-grants-1976_10
Patent number
US03988339

Reaction notes

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