HCID 21393842, compound → HCID 21393877, compound

HRID 1288470Notes

Reaction equation

HRID 1288470 reaction equation
NC1C(C(F)(F)F)=CC=C2C=1C=NC=C2.[F:16][C:17]1[C:18]([C:27]([F:30])([F:29])[F:28])=[CH:19][CH:20]=[C:21]2[C:26]=1[CH:25]=[N:24][CH:23]=[CH:22]2>>[F:16][C:17]1[C:18]([C:27]([F:30])([F:28])[F:29])=[CH:19][CH:20]=[C:21]2[C:26]=1[CH2:25][NH:24][CH2:23][CH2:22]2

Participants

3

Reactant 2

HCID 21393842HCID 21393842, compoundHCID 21393852HCID 21393852, compound

Product 1

HCID 21393877HCID 21393877, compound

Procedure

By the procedure of Example 16, 8-amino-7-trifluoromethylisoquinoline is converted to 8-fluoro-7-trifluoromethylisoquinoline. Hydrogenating by the procedure of Example 9 gives 8-fluoro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Sources & evidence

ORD record
ord-e9ff339388234c90aa87027759bac9d2
Source dataset
uspto-grants-1976_10
Patent number
US03988339

Reaction notes

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