HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Fluoro-7-(trifluoromethyl)isoquinoline → 8-Fluoro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Fluoro-7-(trifluoromethyl)isoquinoline | HCID 21393842 | — |
| Reactant | 8-Amino-7-trifluoromethylisoquinoline | HCID 21393852 | — |
| Product | 8-Fluoro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline | HCID 21393877 | — |
Reaction Steps
By the procedure of Example 16, 8-amino-7-trifluoromethylisoquinoline is converted to 8-fluoro-7-trifluoromethylisoquinoline. Hydrogenating by the procedure of Example 9 gives 8-fluoro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03988339 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-e9ff339388234c90aa87027759bac9d2 |
| Source note | uspto-grants-1976_10 |