Isopropenyl acetate → HCID 20523215, compound

HRID 1288480Notes

Reaction equation

[NH2:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH2:6][CH2:7][NH:8][CH2:9]2)=[CH:4][CH:3]=1.[C:13](OC(C)=C)(=[O:15])[CH3:14]>>[C:13]([N:8]1[CH2:7][CH2:6][C:5]2[C:10](=[C:11]([Cl:12])[C:2]([NH2:1])=[CH:3][CH:4]=2)[CH2:9]1)(=[O:15])[CH3:14]

Participants

Reactant 2

HCID 7916Isopropenyl acetate

HCID 21393795HCID 21393795, compound

Product 1

HCID 20523215HCID 20523215, compound

Procedure

7-Amino-8-chloro-1,2,3,4-tetrahydroisoquinoline is treated with one molar equivalent of isopropenyl acetate by the procedure of Example 15 to give 2-acetyl-7-amino-8-chloro-1,2,3,4-tetrahydroisoquinoline.

Sources & evidence

ORD record: ord-a9cd259d19dc4a06b0065ac7ac08aff7
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03988339

Reaction notes

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