HCID 21393812, compound → HCID 21393870, compound

HRID 1288481Notes

Reaction equation

HRID 1288481 reaction equation
C(N1CCC2C(=C(N)C(C(F)(F)F)=CC=2)C1)(=O)C.C([N:22]1[CH2:31][CH2:30][C:29]2[C:24](=[C:25]([N+:36]([O-:38])=[O:37])[C:26]([C:32]([F:35])([F:34])[F:33])=[CH:27][CH:28]=2)[CH2:23]1)(=O)C>>[N+:36]([C:25]1[C:26]([C:32]([F:35])([F:33])[F:34])=[CH:27][CH:28]=[C:29]2[C:24]=1[CH2:23][NH:22][CH2:31][CH2:30]2)([O-:38])=[O:37]

Participants

3

Reactant 2

HCID 21393812HCID 21393812, compoundHCID 21393846HCID 21393846, compound

Product 1

HCID 21393870HCID 21393870, compound

Procedure

2-Acetyl-8-amino-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline, prepared as in Example 20, is converted to 2-acetyl-8-nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline by the procedure of Example 24. Removing the 2-acetyl group by acid hydrolysis according to the procedure of Example 15 gives 8-nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Workup

  1. customRemoving the 2-acetyl group
  2. customby acid hydrolysis

Sources & evidence

ORD record
ord-abbaaf60a7654f9a81a8d221b3084403
Source dataset
uspto-grants-1976_10
Patent number
US03988339

Reaction notes

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