HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetyl-8-amino-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline → 8-Nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetyl-8-amino-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline | HCID 21393812 | — |
| Reactant | 2-Acetyl-8-nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline | HCID 21393846 | — |
| Product | 8-Nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline | HCID 21393870 | — |
Reaction Steps
2-Acetyl-8-amino-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline, prepared as in Example 20, is converted to 2-acetyl-8-nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline by the procedure of Example 24. Removing the 2-acetyl group by acid hydrolysis according to the procedure of Example 15 gives 8-nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03988339 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-abbaaf60a7654f9a81a8d221b3084403 |
| Source note | uspto-grants-1976_10 |