10H-Phenothiazine, 2-(trifluoromethyl)- → HCID 54240075, compound

HRID 1288539Notes

Reaction equation

HRID 1288539 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][C:5]=2[CH:4]=1.[CH3:19][C:20](=[CH2:24])[C:21](Cl)=[O:22]>C1(C)C=CC=CC=1>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([C:21](=[O:22])[C:20]([CH3:24])=[CH2:19])[C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 708210H-Phenothiazine, 2-(trifluoromethyl)-HCID 13528Methacryloyl chloride

Product 1

HCID 54240075HCID 54240075, compoundYield 53.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

27 g of 2-trifluoromethyl-phenothiazine and 12 g of α-methylacryloyl chloride in 100 ml of toluene were 1 for 2 hours and the mixture was evaporated to dryness. The residue was chromatographed over silica gel and elution with a 1-- 1 benzene-cyclohexane mixture gave 18 g of 2-trifluoromethyl-10-(α-methyl acryloyl)-phenothiazine in the form of white crystals melting at 103°C.

Workup

  1. customfor 2 hours
  2. customthe mixture was evaporated to dryness
  3. customThe residue was chromatographed over silica gel and elution with a 1-- 1 benzene-cyclohexane mixture

Sources & evidence

ORD record
ord-bf69c6936b2b42d384371dc4b9289552
Source dataset
uspto-grants-1976_10
Patent number
US03988453

Reaction notes

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