反应详情

To a mixture containing 5.0 g. of β-chloromethylnaphthalene, 3.0 g. of sodium carbonate and 30 ml. of dimethylformamide is added 4.6 g. of pyrimidinylpiperazine. The mixture is stirred and heated on a steam bath for approximately two hours. The mixture is then cooled, filtered and the filtrate is concentrated to a small volume in vacuo. The residue is washed with water and crystallized from ethanol to yield 1-(β-napthylmethyl)-4-(2-pyrimidinyl)-piperazine having a melting point of 109°-110° C.

1. additionTo a mixture containing 5.0 g
2. temperatureheated on a steam bath for approximately two hours
3. temperatureThe mixture is then cooled
4. filtrationfiltered
5. concentrationthe filtrate is concentrated to a small volume in vacuo
6. washThe residue is washed with water
7. customcrystallized from ethanol