反应详情

温度

45 °C

A mixture of 7.66 g of ethyl α-diazobenzoylacetate, 3.8 g of p-cresol and 150 mg of rhodium(II) acetate in 40 cc of carbon tetrachloride was stirred at a temperature of 40-50° C. for 2 hours. After cooling, the insoluble materials were filtered off and the solvent was distilled off. The crude product thus obtained was purified by a silica gel column chromatography (eluent: chloroform/hexane=1/2) to obtain 2.59 g of compound E. Yield: 24.7%.

1. temperatureAfter cooling
2. filtrationthe insoluble materials were filtered off
3. distillationthe solvent was distilled off
4. customThe crude product thus obtained
5. customwas purified by a silica gel column chromatography (eluent: chloroform/hexane=1/2)